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Bulk DAA vs proprietary blends??

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  • LG1
    replied
    Thx Homon!

    Leave a comment:


  • homonunculus
    replied
    Originally posted by kreilly1656 View Post
    what would you feel the active dose of DAA is, from lets say true proteins product?

    thx
    Originally posted by MachMood View Post
    I think I saw a thread where someone from TP said it had 3g in it, not 100% sure though
    http://www.trueprotein.com/Product_D...id=25&pid=6946

    "The amino acid D-Aspartic Acid (DAA) plays a complex role in the body’s endocrine system. Found in high concentrations in the gonads and pituitary, either via its synthesis there for via uptake from the blood(7), it stimulates hormonal release from those glands, including growth hormone (GH), gonadotrophin releaseasing hormone (GnRH), luteinizing hormone (LH) and testosterone(1). Like LH (and HCG)(6), DAA also increases testicular aromatase activity(4), promoting the conversion of testosterone to estrogen and thus balancing it’s own gonadotrophic stimulus(7). Not surprisingly, research from the lab of the most prominent researcher of DAA’s metabolic effects, Gemma D’Aniello, indicates that lower levels of DAA are associated with reduced sex cell (sperm(3) and oocyte(2)) quality in humans.

    The profound role of DAA in regulating steroidogenesis prompted D’Aniello’s group to investigate the effects of oral administration of DAA in both rats and humans(7). Rats given drinking water supplemented with DAA demonstrated a ~7 fold increase in DAA in testicular and pituitary tissue, triggering an intracellular 2nd messenger (cAMP and cGMP) mechanism and elevating blood LH (~50%) and testosterone (over 100%!). Importantly, L-Aspartic acid, the amino acid found in food and a typical protein supplement, had no such hormonal effects in the rodents.
    In men, a single morning dose of just over 3 grams per day (roughly equivalent to the daily rodent dose in this study(5)) increased LH (33%) and testosterone (42%) after 12 consecutive days of consumption. This effect was noted in 90% of their subjects but was not apparent after 6 days of supplementation. Additionally, blood testosterone (but not LH) was elevated for an additional 3 days after discontinuing the DAA supplement, which they suggest was likely due to residual DAA in the testes.

    Supplement Use
    The limited research on DAA suggests that a single oral dose of ~3g / day begins to produce significant hormonal effects by the second week of supplementation in most men, elevating luteinizing hormone and testosterone by ~25-50%. Animal data also suggest that other pituitary hormones like GH might be increased by DAA, as well. The effects of long-term DAA consumption is not known at this time, so caution is advised. DAA could be taken alone or in conjunction with other supplements that act synergistically to elevate testosterone or have related effects (e.g., Long Jack, Tribulus Terrestris, Maca, MG’s Super Test Booster, Yohimbine, or Horny Goat Weed), that inhibit cortisol’s effects (e.g., Cissus Quandrangularis), that elevate thyroid output like (e.g., Guggulsterones), or that ameliorate the adverse effects of elevated testosterone or estrogen (e.g., 3,3’-Diindolylmethane or DIM).

    DISCLAIMER: The above description is provided for information only and does not constitute medical advice. Please consult your physician or the appropriately licensed professional before engaging in a program of exercise of nutritional supplementation.

    Serving Size: 1 Capsule.
    Servings Per Container: 120.

    Directions: As a dietary supplement, clinical studies have proven results using 3-3.5g of material used in a single serving daily.

    Active Ingredients: D-Aspartic Acid.

    Inactive Ingredients: Magnesium Sterate, Gelatin (Capsule).

    The amino acid D-Aspartic Acid (DAA) plays a complex role in the body’s endocrine system. Found in high concentrations in the gonads and pituitary, either via its synthesis there for via uptake from the blood(7), it stimulates hormonal release from those glands, including growth hormone (GH), gonadotrophin releaseasing hormone (GnRH), luteinizing hormone (LH) and testosterone(1). Like LH (and HCG)(6), DAA also increases testicular aromatase activity(4), promoting the conversion of testosterone to estrogen and thus balancing it’s own gonadotrophic stimulus(7). Not surprisingly, research from the lab of the most prominent researcher of DAA’s metabolic effects, Gemma D’Aniello, indicates that lower levels of DAA are associated with reduced sex cell (sperm(3) and oocyte(2)) quality in humans.

    The profound role of DAA in regulating steroidogenesis prompted D’Aniello’s group to investigate the effects of oral administration of DAA in both rats and humans(7). Rats given drinking water supplemented with DAA demonstrated a ~7 fold increase in DAA in testicular and pituitary tissue, triggering an intracellular 2nd messenger (cAMP and cGMP) mechanism and elevating blood LH (~50%) and testosterone (over 100%!). Importantly, L-Aspartic acid, the amino acid found in food and a typical protein supplement, had no such hormonal effects in the rodents.
    In men, a single morning dose of just over 3 grams per day (roughly equivalent to the daily rodent dose in this study(5)) increased LH (33%) and testosterone (42%) after 12 consecutive days of consumption. This effect was noted in 90% of their subjects but was not apparent after 6 days of supplementation. Additionally, blood testosterone (but not LH) was elevated for an additional 3 days after discontinuing the DAA supplement, which they suggest was likely due to residual DAA in the testes.

    Supplement Use
    The limited research on DAA suggests that a single oral dose of ~3g / day begins to produce significant hormonal effects by the second week of supplementation in most men, elevating luteinizing hormone and testosterone by ~25-50%. Animal data also suggest that other pituitary hormones like GH might be increased by DAA, as well. The effects of long-term DAA consumption is not known at this time, so caution is advised. DAA could be taken alone or in conjunction with other supplements that act synergistically to elevate testosterone or have related effects (e.g., Long Jack, Tribulus Terrestris, Maca, MG’s Super Test Booster, Yohimbine, or Horny Goat Weed), that inhibit cortisol’s effects (e.g., Cissus Quandrangularis), that elevate thyroid output like (e.g., Guggulsterones), or that ameliorate the adverse effects of elevated testosterone or estrogen (e.g., 3,3’-Diindolylmethane or DIM).

    DISCLAIMER: The above description is provided for information only and does not constitute medical advice. Please consult your physician or the appropriately licensed professional before engaging in a program of exercise of nutritional supplementation.

    Allergen Warnings: This product is free from all forms of shell fish, tree nuts, yeast, gluten, salt, preservatives, artificial ingredients, lactose, and soy. This product is manufactured in a facility that handles soy, gluten, and milk products. This product contains the preservative Magnesium Stearate.

    Packaging: This product is packaged in a plastic container with an interior pressure-sensitive lining, exterior tamper-evident band, and desiccant packet to ensure product integrity.

    Vegan or Vegetarian Safe: This material is synthetically derived, but can often originate from animal byproducts. The capsule source is gelatin for this item, which will not be vegan or vegetarian friendly.

    Shelf Life: This product will retain a 2 year shelf life from the date of manufacturer if properly sealed and stored in a dry, cool environment outside of direct sunlight.

    Questions or comments on this product? Please feel free to post them in the True Protein Forums!

    http://forums.trueprotein.com/

    References
    1. D'Aniello A. D-Aspartic acid: an endogenous amino acid with an important neuroendocrine role. Brain Res Rev 53: 215-234, 2007.
    2. D'Aniello G, Grieco N, Di Filippo MA, Cappiello F, Topo E, D'Aniello E, and Ronsini S. Reproductive implication of D-aspartic acid in human pre-ovulatory follicular fluid. Hum Reprod 22: 3178-3183, 2007.
    3. D'Aniello G, Ronsini S, Guida F, Spinelli P, and D'Aniello A. Occurrence of D-aspartic acid in human seminal plasma and spermatozoa: possible role in reproduction. Fertil Steril 84: 1444-1449, 2005.
    4. Lamanna C, Assisi L, Botte V, and Di Fiore MM. Involvement of D-Asp in P450 aromatase activity and estrogen receptors in boar testis. Amino Acids 32: 45-51, 2007.
    5. Rogers VV, Wickstrom M, Liber K, and MacKinnon MD. Acute and subchronic mammalian toxicity of naphthenic acids from oil sands tailings. Toxicol Sci 66: 347-355, 2002.
    6. Rommerts FF, and Brinkman AO. Modulation of steroidogenic activities in testis Leydig cells. Mol Cell Endocrinol 21: 15-28, 1981.
    7. Topo E, Soricelli A, D'Aniello A, Ronsini S, and D'Aniello G. The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats. Reprod Biol Endocrinol 7: 120, 2009.
    "

    -S

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  • LG1
    replied
    Originally posted by MachMood View Post
    I think I saw a thread where someone from TP said it had 3g in it, not 100% sure though
    Correct! Similar to the dosage in MG's Test Booster product:tongue1:

    Leave a comment:


  • MachMood
    replied
    My question was kinda of vague, assuming all DAA products contain the same amount of DAA, is it worth spending extra for those added ingrediants. MOst products I have seen have good ingrediants but underdosed so IMO not worth the extra money

    Leave a comment:


  • MachMood
    replied
    I think I saw a thread where someone from TP said it had 3g in it, not 100% sure though

    Leave a comment:


  • kreilly1656
    replied
    what would you feel the active dose of DAA is, from lets say true proteins product?

    thx

    Leave a comment:


  • VanillaGorilla3
    replied
    It would depend on the legitimacy of the other ingredients. Certainly beneficial if you were using those other ingredients in your day. Though, I would only use a product that detailed how much DAA was in the blend.

    Leave a comment:


  • MachMood
    started a topic Bulk DAA vs proprietary blends??

    Bulk DAA vs proprietary blends??

    True protein sells a month worth of DAA pills for 14$ when other company's sell blends with DAA in it for double or tripple the price. Just wondering if the extra $ is worth it seeing almost all the bloodwork on DAA has been done using just plain DAA not mixed with anything?
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