ok so i started my hgh research

[supermanxx]

i started my research on mon my test animal will recive 3iu's a day after its evening excersise around 8pm..it will also recive 40mcg of igf-1 apoun rising in the am the animal will continue this regiman untill late july where as at that point some AS will be added to the mix

my animals starting stats are 225lbs about 12%bf
my animal will be doing cardio 5days a week in the am as well as eating about 500-700 grams of protien a day and about 30-100 carbs a day mostly befre 2pm only carbs after 2pm are fibourous and post work out shake

comments are welcome

i have one question when injecting the hgh in my animal do i inject it under the fat in the skin fold or above the fat

thanks

also i am doing this research in the beg with out as to see what kind of gains can be made with the 2 compounds listed

[GetnBigr]

I'm no hgh expert, but I'm sure I've read that you shouldn't take hgh before you go to sleep because that's when your body releases its own.

more opnions.......

[supermanxx]

yea i have heard conflicting things about that i have talked to ppl that have done it all dif ways split up doses...single dose in am...single dose pm..... and they all have said they have seen amazing results i dont usaly goto bed till like midnight


the only thing is i dont keep it home due to certin curcumstances so the earliest i can prob take it is maybe like 4ish

[joshb]

chad nicholls recommends it right before bed

[Anadrol]

Originally posted by supermanxx
my animals starting stats are 225lbs about 12%bf
my animal will be doing cardio 5days a week in the am as well as eating about 500-700 grams of protien a day and about 30-100 carbs a day mostly befre 2pm only carbs after 2pm are fibourous and post work out shake

Wow.. that a big animal

i have one question when injecting the hgh in my animal do i inject it under the fat in the skin fold or above the fat

GH can be injected both intramuscular and subcutaneous...
Hmm... under or above the fat? how about right in the fat?

[supermanxx]

Originally posted by Anadrol
Wow.. that a big animal



GH can be injected both intramuscular and subcutaneous...
Hmm... under or above the fat? how about right in the fat?

lol yea pooor animal was bigger but due to a south beach vacation in march and dieting for the summer it has lost some weight

[joshb]

subcu. it is absorbed too fast intramuscularly.

[supermanxx]

yea i kno subq but i was wondering if when i pinch the skin should i do it under the fat layer or above it?

[homonunculus]

Originally posted by joshb
subcu. it is absorbed too fast intramuscularly.

Interesting... Where did you learn this?...

This is the opposite of what happens with insulin and not what I have found in perusing the lit...

1. Zeisel, H. J., W. von Petrykowski, and U. Wais. Pharmacokinetics and short-term metabolic effects of mammalian cell-derived biosynthetic human growth hormone in man. Horm Res. 37 Suppl 2:5-13, 1992.

The pharmacokinetics and acute effects of an authentic recombinant DNA-derived human growth hormone (rhGH) produced by genetically engineered mammalian cells were determined in 12 healthy volunteers following intravenous (i.v.), intramuscular (i.m.) and subcutaneous (s.c.) administration of 4 IU (1.3 mg) hGH/m2 body surface area. Following i.v. administration, apparent elimination half-life of rhGH was 18 min. Following i.m. administration, a mean peak serum concentration of 36.9 ng/ml (range 13-61 ng/ml) occurred at 3 h, and following s.c. administration, more sustained but lower serum concentrations occurred, with mean peak concentrations of 16.4 and 16.3 ng/ml at 4 and 6 h (ranges 9.0-27.5 ng/ml and 6.5-35.5 ng/ml at 4 and 6 h, respectively). The mean area under the curves was lower after s.c. (134 +/- 48 ng.h.ml-1) than after i.m. (194 +/- 48 ng.h.ml-1) injections (p < 0.03). Comparable results were obtained for the same dose of rhGH given subcutaneously in concentrations of either 4 IU/ml or 10 IU/ml. Both i.m. and s.c. administrations caused similar increases in free fatty acids at 4 h and insulin-like growth factor I at 24 h. Insulin, C-peptide and blood glucose were almost unchanged during the first 4 h after administration, whereas leukocytes increased significantly (p < 0.0001). Local and systemic tolerance were good, and no adverse reactions were observed. In a GH-deficient child, hGH serum levels between 10 and 20 ng/ml were demonstrated for a period of 8 h after s.c. administration of 0.07 IU rhGH/kg body weight.

--------
Note that this review suggests that *evening* injections are better for stimulating growth (in deficient children), indicating a greater metabolic effect.

1. Jorgensen, J. O., J. Moller, N. Moller, T. Lauritzen, and J. S. Christiansen. Pharmacological aspects of growth hormone replacement therapy: route, frequency and timing of administration. Horm Res. 33 Suppl 4:77-82, 1990.
Two or three weekly, daytime intramuscular injections of GH has been the traditional treatment of GH deficiency since the first studies. A recent reevaluation of the feasibility of subcutaneous GH injections revealed no side-effects, but a very strong preference by the patients for the subcutaneous route, and also an increase in growth rate in studies where the patients received daily injections given in the evening. That could indicate that the route, frequency and timing of GH administration may be of clinical importance. Subcutaneous injections result in a slower absorption, a smaller peak value, and a prolonged serum disappearance phase compared to intramuscular injections. This extends the periods of elevated serum GH levels in the patient, which might be advantageous. On the other hand, a reduced bioavailability of GH by the subcutaneous route has also been reported. The frequency of subcutaneous injections correlates positively with growth rate in animal studies. This is commonly ascribed to a closer resemblance to the endogenous pulsatile pattern. However, frequent subcutaneous injections do not induce a pulsatile pattern, but a pattern which is intermediary between continuous and true pulsatile administration. In a short-term patient study, we observed that pulsatile and continuous intravenous administration of GH generated identical increases in serum insulin-like growth factor I, which suggests that both pulsatory and constant, small elevations in serum GH are important for its actions. Concerning the time of administration, evening GH injections yield a more physiological pattern, and it has been shown that evening GH administration induces increased nitrogen retention and is more successful in normalizing circadian patterns of pertinent hormones and metabolites.(ABSTRACT TRUNCATED AT 250 WORDS)

-Randy

[supermanxx]

thanks for the info randy def good read